INCORPORATION OF INOSITOL HEXAPHOSPHATE INTO INTACT RED BLOOD-CELLS .2. ENHANCEMENT OF GAS-TRANSPORT IN INOSITOL HEXAPHOSPHATE-LOADED RED BLOOD-CELLS

被引：18

作者：

GERSONDE, K ^{[1
]}

NICOLAU, C ^{[1
]}

机构：

[1] MAX PLANCK INST COAL RES,INST STRAHLEN,D-4330 MULHEIM,FED REP GER

来源：

NATURWISSENSCHAFTEN | 1979年 / 66卷 / 11期

关键词：

D O I：

10.1007/BF00368811

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The gas-transport function of red blood cells which have incorporated inositol hexaphosphate is significantly improved by fusion with effector-loaded lipid vesicles. Right-shifts" of the O2-binding curves of inositol hexaphosphate-loaded red blood cells with half-saturation pressures at 37 °C up to 98 mmHg are observed. The transformation of 56% of the intracellular haemoglobin into the low affinity state corresponds to an optimum increase of the O2-release capacity of 270%. The CO2 transport is also correspondingly enhanced. The treated red blood cells show no inositol hexaphosphate depletion during a reasonable time. © 1979 Springer-Verlag."

引用

页码：567 / 570

页数：4

共 17 条

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