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EPIDERMAL GROWTH-FACTOR IN URINE FROM THE PATIENTS WITH UROTHELIAL TUMORS
被引：21
作者：
FUSE, H
MIZUNO, I
SAKAMOTO, M
KATAYAMA, T
机构：
[1] Department of Urology, Faculty of Medicine, Toyama Med. and Pharmaceutical, Toyama 930-01
关键词：
EPIDERMAL GROWTH FACTOR;
UROTHELIAL TUMOR;
D O I：
10.1159/000282347
中图分类号：
R5 [内科学];
R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ;
100201 ;
摘要：
Epidermal growth factor (EGF) concentration in urine was measured with a radioimmunoassay in 40 untreated patients with urothelial tumors and a comparable control group of 25 normals. The concentration of EGF in urine from the patients with bladder, renal pelvic or ureter tumors was lower than normal (p < 0.05). Patients with T4 tumors had lower concentrations of EGF compared with those of other stages. EGF concentrations after transurethral resection of bladder tumors were significantly elevated compared with the values before operation. These findings suggest that urothelial tumors are related to a low concentration of EGF and that a decrease of EGF is associated with invasion of tumors.
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页码：261 / 264
页数：4
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