1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) REDUCES NOREPINEPHRINE CONCENTRATIONS IN THE OLFACTORY BULBS OF MALE-MICE

被引：14

作者：

DLUZEN, DE

机构：

[1] Department of Anatomy, Northeastern Ohio Universities, College of Medicine, Rootstown

来源：

BRAIN RESEARCH | 1992年 / 586卷 / 01期

关键词：

OLFACTORY BULB; HYPOTHALAMUS; NOREPINEPHRINE; DOPAMINE; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP); PARKINSONS DISEASE;

D O I：

10.1016/0006-8993(92)91385-R

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Male retired breeder C57/Bl and CD-1 mice were treated with either MPTP or its vehicle. At 7-10 days post-treatment, catecholamine concentrations within the olfactory bulbs (OB) and hypothalamus were determined. Norepinephrine concentrations within the OB were significantly decreased in MPTP-treated mice. These effects were more pronounced in the CD-1 (50% reduction) compared to the C57/Bl (20% reduction) strain. No effects of MPTP were observed on norepinephrine concentrations within the hypothalamus. Dopamine concentrations in the OB and hypothalamus did not differ between MPTP- and vehicle-treated mice in either strain. Overall, catecholamine concentrations within the OB, but not the hypothalamus, were significantly greater in C57/Bl compared to CD-1 mice. The reduction in OB norepinephrine concentration in the MPTP-treated animals may be related to the olfactory deficits which accompany Parkinson's disease.

引用

页码：144 / 147

页数：4

共 21 条

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