2 TYROSINASE NONAPEPTIDES RECOGNIZED ON HLA-A2 MELANOMAS BY AUTOLOGOUS CYTOLYTIC T-LYMPHOCYTES

被引：357

作者：

WOLFEL, T

VANPEL, A

BRICHARD, V

SCHNEIDER, J

SELIGER, B

ZUMBUSCHENFELDE, KHM

BOON, T

机构：

[1] LUDWIG INST CANC RES, BRUSSELS, BELGIUM

[2] UNIV CATHOLIQUE LOUVAIN, CELLULAR GENET UNIT, BRUSSELS, BELGIUM

[3] UNIV MAINZ, MED KLIN & POLIKLIN 3, HAMATOL ABT, D-55131 MAINZ, GERMANY

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1994年 / 24卷 / 03期

关键词：

HUMAN MELANOMA; PEPTIDE ANTIGENS; AUTOLOGOUS CTL; TYROSINASE; HLA-A2;

D O I：

10.1002/eji.1830240340

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A number of cytolytic T lymphocyte (CTL) clones derived from several melanoma patients have been found to recognize a majority of melanomas from HLA-A2 patients. We have reported previously that two such CTL clones recognize a product of the tyrosinase gene that is presented by HLA-A2. Here we show that one of these CTL clones recognizes a peptide encoded by the first nine amino acids of the putative signal sequence of tyrosinase. The other CTL clone recognizes a different tyrosinase peptide corresponding to amino acids 368-376. Both peptides contain consensus motifs of HLA-A2 binding peptides.

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页码：759 / 764

页数：6

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