THE POWER-CONSUMPTION-CONTROLLED EXTRUDER - A TOOL FOR PELLET PRODUCTION

被引:29
作者
KLEINEBUDDE, P
SOLVBERG, AJ
LINDNER, H
机构
[1] Department of Pharmaceutics and Biopharmaceutics, Christian- Albrechts-University, Kiel, 24118
关键词
D O I
10.1111/j.2042-7158.1994.tb03853.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Based on the assumption that there is a link between power consumption of an extruder and pellet properties, a control circuit for power consumption was developed. Powder and granulation liquid are feeded separately into a twin-screw extruder. The power consumption is controlled by varying the pump rate at a given powder-feed rate; consequently each level of power consumption results in a specific water content of the extrudate for a particular formulation. The shape of pellets depends almost entirely on the level of power consumption irrespective of formulation. The size of dry pellets is additionally affected by a shrinking factor which depends on the water content. The power-consumption-controlled extruder is an appropriate tool for the production of pellets. The system is able to adapt the water content for a formulation automatically.
引用
收藏
页码:542 / 546
页数:5
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