GROWTH-FACTORS CAN PROTECT B-CHRONIC LYMPHOCYTIC-LEUKEMIA CELLS AGAINST PROGRAMMED CELL-DEATH WITHOUT STIMULATING PROLIFERATION

被引：18

作者：

JEWELL, AP

LYDYARD, PM

WORMAN, CP

GILES, FJ

GOLDSTONE, AH

机构：

[1] Department of Haematology, University College London Medical School, London

[2] Immunology, University College London Medical School, London

来源：

LEUKEMIA & LYMPHOMA | 1995年 / 18卷 / 1-2期

关键词：

CLL; CYTOKINES; APOPTOSIS;

D O I：

10.3109/10428199509064937

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The proliferation and survival of B-chronic lymphocytic leukaemia (B-CLL) cells may be regulated by autocrine growth factor loops, Furthermore, it has been suggested the reduction in lymphocytosis following therapy with interferon-alpha may be associated with the interruption of autocrine growth factor production. We have therefore examined the effects of a number of cytokines on the proliferation of B-CLL cells, and also on the regulation of programmed cell death, and the role of interferon-alpha in these systems, In the ten patients studied, neither interferon-alpha alone or together with either interferon-gamma, IL1, II4, IL6, TNF, or serum containing high levels of soluble CD23 was able to induce proliferation of B-CLL cells. Incubation with TPA or IL2 resulted in variable proliferative responses, Go-incubation with interferon-alpha enhanced TPA-induced proliferation in 4 cases, but reduced IL2-induced proliferation in all cases studied. In contrast, all the cytokines studied were able to protect B-CLL cells against programmed cell death, both spontaneous and that induced by hydrocortisone, with the exception of TNF. These data suggest a role for interferon-alpha in disrupting autocrine survival pathways rather than inhibiting proliferation.

引用

页码：159 / 162

页数：4

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