MYOCARDIAL ATRIAL-NATRIURETIC-FACTOR GENE-EXPRESSION AFTER CORONARY LIGATION IN RATS

被引：12

作者：

KANDA, T ^{[1
]}

NAKANO, M ^{[1
]}

ARAI, M ^{[1
]}

YAMAMOTO, A ^{[1
]}

SUZUKI, T ^{[1
]}

MURATA, K ^{[1
]}

机构：

[1] GUNMA UNIV,SCH MED,DEPT HYG,MAEBASHI,GUNMA 371,JAPAN

来源：

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY | 1993年 / 101卷 / 03期

关键词：

ANF-GENE EXPRESSION; MYOCARDIAL INFARCTION; RAT;

D O I：

10.1055/s-0029-1211226

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The atrial natriuretic factor (ANF) messenger RNA (mRNA) content was determined in a rat model of acute myocardial infarction. Non-infarcted tissue of left and right ventricles were examined soon after ligation of the left descending anterior coronary artery. In the left ventricles, ANF mRNA/alpha-actin mRNA ratio increased to reach a maximum on day 7 and was sustained while in the right ventricle, the maximum was reached on day 1. The plasma ANF was significantly (p < 0.01) elevated from days 1 to 28 after coronary ligation. The primary compensatory response of ANF within the first 7 day's may be attributed not only its synthesis in the left ventricle but also to its generation in the right ventricle in acute heart failure.

引用

页码：173 / 177

页数：5

共 17 条

[1] CARDIAC AND NONCARDIAC ATRIAL NATRIURETIC FACTOR (ANF) BIOSYNTHESIS AND STORAGE AND PLASMA ANF IN THE RAT MODEL OF CHRONIC VENTRICULAR DYSFUNCTION [J].