MUTATION IN A HETEROCHROMATIN-SPECIFIC CHROMOSOMAL PROTEIN IS ASSOCIATED WITH SUPPRESSION OF POSITION-EFFECT VARIEGATION IN DROSOPHILA-MELANOGASTER

被引:482
作者
EISSENBERG, JC
JAMES, TC
FOSTERHARTNETT, DM
HARTNETT, T
NGAN, V
ELGIN, SCR
机构
[1] WESLEYAN UNIV,DEPT MOLEC BIOL & BIOCHEM,MIDDLETOWN,CT 06457
[2] WASHINGTON UNIV,DEPT BIOL,ST LOUIS,MO 63130
关键词
aberrant pre-mRNA splicing; dominant suppression of heterochromatic position effects; heterochromatin-associated protein;
D O I
10.1073/pnas.87.24.9923
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
We report here that a point mutation in the gene which encodes the heterochromatin-specific nonhistone chromosomal protein HP-1 in Drosophila melanogaster is associated with dominant suppression of position-effect variegation. The mutation, a G-to-A transition at the first nucleotide of the last intron, causes missplicing of the HP-1 mRNA. This suggests that heterochromatin-specific proteins play a central role in the gene suppression associated with heterochromatic position effects.
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页码:9923 / 9927
页数:5
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