ADRIAMYCIN INSTILLATION THERAPY FOR BLADDER-TUMORS

Mishina, T., Fujiwara, T., Miyakoda, K., Araki, H., Kobayashi, T., Saitoh, M. and Watanabe, H. Adriamycin Instillation Therapy for Bladder Tumors. Tohoku J. exp. Med., 1979, 127 (4), p.339-343 Topical instillation of Adriamycin, 40 mg in 20 ml sterilized distilled water, was performed in 20 cases of bladder tumors every day for two weeks. In 8 cases (40%) the tumors disappeared completely, while in 5 cases (25%) tumors were reduced in size, but in 7 cases (35%) there was no effect. Therefore, the rate of effectiveness was 65%. The local bladder reaction and urethral pain were noted in all cases, as a result of which the therapy was interrupted in 2 cases. Abnormal values of red blood cells, white blood cells and platelets were not observed. In 3 cases the serum level of Adriamycin was only trace 1 or 2 hr after instillation. In conclusion, Mitomycin C was thought to be superior to Adriamycin as far as the effectiveness and irritability on the normal bladder epithelium were concerned. Adriamycin; topical therapy; bladder tumor Topical therapy for bladder tumor was first described by Semple (1948) who used podophyllin on 4 patients with bladder papilloma. Thereafter, the effectiveness of thio-TEPA as topical therapy for the superficial bladder tumor was reported by many researchers (Bateman 1955; Jones and Swinney 1961). Mitomycin C instillation therapy for bladder tumor with satisfactory results was reported by Shida (1967) and Mishina (1975). © 1979, Tohoku University Medical Press. All rights reserved.