NATURAL INTERFERON-BETA AND ANDROGEN RECEPTORS IN PROSTATIC-CANCER CELLS

被引：19

作者：

SICA, G

FABBRONI, L

DELLACQUA, G

IACOPINO, F

MARCHETTI, P

CACCIATORE, M

PAVONEMACALUSO, M

机构：

[1] Instituto di Istologia ed Embriologia Generale, Università Cattolica del S. Cuore, Roma

[2] Oncologia Medica, Università de l’Aquila

[3] Istituto di Clinica Urologica, Università di Palermo

来源：

UROLOGIA INTERNATIONALIS | 1991年 / 46卷 / 02期

关键词：

INTERFERON-BETA; ANDROGEN RECEPTORS; PROSTATIC CANCER CELLS;

D O I：

10.1159/000282123

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Both PC-3 and DU-145 cell lines are androgen-insensitive, but, in our experience, they contain androgen receptors (AR). Treatment of these cells with natural beta-interferon at a concentration of 1,000 IU/ml of culture medium determines an increase of AR (evaluated by a whole-cell assay), statistically significant with respect to control. Androgen unresponsiveness of our cells could be due to an AR level which is lower than that present in hormone-sensitive prostatic cancer cell lines, such as LNCaP cells. For this reason, interferon-promoted AR increase merits further investigation, even if other defects in receptor mechanism, responsible for hormone insensitivity, cannot be excluded.

引用

页码：159 / 162

页数：4

共 18 条

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