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THE EXPRESSION OF HUMAN INTERCELLULAR-ADHESION MOLECULE-2 IS REFRACTORY TO INFLAMMATORY CYTOKINES

被引：105
作者：
NORTAMO, P
LI, R
RENKONEN, R
TIMONEN, T
PRIETO, J
PATARROYO, M
GAHMBERG, CG
机构：
[1] UNIV HELSINKI,DEPT BIOCHEM,UNIONINKATU 35,SF-00170 HELSINKI 17,FINLAND
[2] UNIV HELSINKI,DEPT BACTERIOL & IMMUNOL,SF-00170 HELSINKI 17,FINLAND
[3] UNIV HELSINKI,DEPT PATHOL,SF-00170 HELSINKI 17,FINLAND
[4] KAROLINSKA INST,DEPT IMMUNOL,S-10401 STOCKHOLM 60,SWEDEN
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 1991年 / 21卷 / 10期
关键词：
D O I：
10.1002/eji.1830211049
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The beta-2-intergrin CD11a/CD18 binds to the intercellular adhesion molecules (ICAM)-1 (CD54) and ICAM-2. ICAM-1 has a wide distribution, and its expression is up-regulated by various cytokines. In contrast, ICAM-2 has a more restricted distribution, and is mainly expressed on endothelial cells. In the present study we show that it is not induced by inflammatory cytokines or other treatments on any of several cells studied. Moreover, antibodies to the intercellular adhesion ligands were not able to block all CD11a/CD18-dependent adhesion, indicating the presence of additional CD11a/CD18 ligands.
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收藏
页码：2629 / 2632
页数：4
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