FORMATION, STABILITY AND REMOVAL OF PYRIMIDINE DAMAGE IN DNA

被引：1

作者：

BOORSTEIN, RJ

CADET, J

HILBERT, T

LUSTIG, M

ODONNELL, R

ZUO, S

TEEBOR, G

机构：

[1] CEN, SESAM, DRFMC, LESIONS ACIDES NUCL LAB, F-38041 GRENOBLE, FRANCE

[2] NYU, SCH MED, DEPT PATHOL, NEW YORK, NY 10016 USA

来源：

JOURNAL DE CHIMIE PHYSIQUE ET DE PHYSICO-CHIMIE BIOLOGIQUE | 1993年 / 90卷 / 04期

关键词：

D O I：

10.1051/jcp/1993900837

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Radiation and oxidation agents damage the pyrimidine bases of DNA. The resulting modified bases can be recognized by enzymes which effect the removal of base lesions, leaving an apurinic site in the DNA backbone. We have been studying three distinct classes of pyrimidine base damage: a) saturation of the 5,6-ethylenic bond to produce the corresponding glycol, b) hydration of the 5,6 double bond to produce the corresponding 6-hydroxy-5,6-dihydroderivative, and c) oxidation of the methyl group of thymine and 5-methylcytosine to produce the corresponding hydroxymethylated compound.

引用

页码：837 / 852

页数：16

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