ANALYSIS OF MESIAL TEMPORAL SEIZURE ONSET AND PROPAGATION USING THE DIRECTED TRANSFER-FUNCTION METHOD

The directed transfer function (DTF) method, a multichannel parametric method of analysis based on an autoregressive model, is a newly developed tool that permits determination of patterns of flow of activity. The DTF method of analysis was applied to seizures originating from mesial temporal lobe structures in 3 patients recorded by combined subdural grid and depth electrode arrays. These first applications to human intracranial recordings demonstrated that the DTF method can accurately determine patterns of seizure onset and propagation. In addition the DTF method can provide evidence regarding patterns of flow of seizure activity that are not readily apparent from visual inspection of the EEG recordings. Important considerations for appropriate application of the DTF method for the analysis of intracranial ictal recordings are discussed.