DESIGN, SYNTHESIS, AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF 2-SUBSTITUTED-2-AMINO-1,3-PROPANEDIOLS - DISCOVERY OF A NOVEL IMMUNOSUPPRESSANT, FTY720

被引：300

作者：

ADACHI, K

KOHARA, T

NAKAO, N

ARITA, M

CHIBA, K

MISHINA, T

SASAKI, S

FUJITA, T

机构：

[1] TAITO CO LTD,RES LAB,NAGATA KU,KOBE 653,JAPAN

[2] KYOTO UNIV,FAC PHARMACEUT SCI,SAKYO KU,KYOTO 60601,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 08期

关键词：

D O I：

10.1016/0960-894X(95)00127-F

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

FTY720 (2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-hydrochloride), a novel synthetic immunosuppressant led by modification of ISP-I (myriocin, thermozymocidin) displayed potent immunosuppressive activity both in vitro and in vivo.

引用

页码：853 / 856

页数：4

共 12 条

[1]

FEUER H, 1963, TETRAHEDRON S1, V19, P57

[2]

FUNGAL METABOLITES .11. A POTENT IMMUNOSUPPRESSIVE ACTIVITY FOUND IN ISARIA-SINCLAIRII METABOLITE [J].

FUJITA, T ;

INOUE, K ;

YAMAMOTO, S ;

IKUMOTO, T ;

SASAKI, S ;

TOYAMA, R ;

CHIBA, K ;

HOSHINO, Y ;

OKUMOTO, T .

JOURNAL OF ANTIBIOTICS, 1994, 47 (02) :208-215

[3]

FUJITA T, BIOMED CHEM

[4]

FK-506, A NOVEL IMMUNOSUPPRESSANT ISOLATED FROM A STREPTOMYCES .1. FERMENTATION, ISOLATION, AND PHYSICOCHEMICAL AND BIOLOGICAL CHARACTERISTICS [J].

KINO, T ;

HATANAKA, H ;

HASHIMOTO, M ;

NISHIYAMA, M ;

GOTO, T ;

OKUHARA, M ;

KOHSAKA, M ;

AOKI, H ;

IMANAKA, H .

JOURNAL OF ANTIBIOTICS, 1987, 40 (09) :1249-1255

[5]

CALCINEURIN IS A COMMON TARGET OF CYCLOPHILIN-CYCLOSPORINE-A AND FKBP-FK506 COMPLEXES [J].

LIU, J ;

FARMER, JD ;

LANE, WS ;

FRIEDMAN, J ;

WEISSMAN, I ;

SCHREIBER, SL .

CELL, 1991, 66 (04) :807-815

[6]

DESIGNING PEPTIDE MIMETICS [J].

MOORE, GJ .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1994, 15 (04) :124-129

[7]

CHEMISTRY AND BIOLOGY OF THE IMMUNOPHILINS AND THEIR IMMUNOSUPPRESSIVE LIGANDS [J].

SCHREIBER, SL .

SCIENCE, 1991, 251 (4991) :283-287

[8]

IMMUNOPHILIN-SENSITIVE PROTEIN PHOSPHATASE ACTION IN CELL SIGNALING PATHWAYS [J].

SCHREIBER, SL .

CELL, 1992, 70 (03) :365-368

[9]

STRUCTURE OF FK506 - A NOVEL IMMUNOSUPPRESSANT ISOLATED FROM STREPTOMYCES [J].

TANAKA, H ;

KURODA, A ;

MARUSAWA, H ;

HATANAKA, H ;

KINO, T ;

GOTO, T ;

HASHIMOTO, M ;

TAGA, T .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (16) :5031-5033

[10]

1991, TRANSPLANT P, V23, P3071

← 1 2 →