THE PHARMACOLOGICAL EFFECTS OF CADMIUM ON SKELETAL NEUROMUSCULAR-TRANSMISSION

被引：15

作者：

BRAGA, MFM ^{[1
]}

ROWAN, EG ^{[1
]}

机构：

[1] UNIV STRATHCLYDE, STRATHCLYDE INST DRUG RES, DEPT PHYSIOL & PHARMACOL, GLASGOW G1 1XW, LANARK, SCOTLAND

来源：

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1994年 / 25卷 / 08期

关键词：

CADMIUM; NEUROMUSCULAR TRANSMISSION; CALCIUM CHANNELS; CYSTEINE;

D O I：

10.1016/0306-3623(94)90379-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Cadmium (100 mu M) blocks neuromuscular transmission by blocking prejunctional voltage dependent calcium channels in a competitive manner. 2. Prolonged exposure to cadmium leads to a block of neuromuscular transmission that is not competitive. 3. Cadmium can increase the spontaneous release of acetylcholine, this release is modified by the cation composition of the bathing solution. 4. Cadmium may enter the nerve terminal via the voltage dependent calcium channels (the L-type calcium channel has been implicated) and exert some of its actions intracellularly. 5. All of the extracellular effects of cadmium can be reversed by cysteine.

引用

页码：1729 / 1739

页数：11

共 51 条

[1] EFFECTS OF CHARYBDOTOXIN, A BLOCKER OF CA-2+-ACTIVATED K+ CHANNELS, ON MOTOR-NERVE TERMINALS [J].

ANDERSON, AJ ;

HARVEY, AL ;

ROWAN, EG ;

STRONG, PN .

BRITISH JOURNAL OF PHARMACOLOGY, 1988, 95 (04) :1329-1335

[2]

BRAGA M F M, 1991, British Journal of Pharmacology, V104, p189P

[3] REVERSAL BY CYSTEINE OF THE CADMIUM-INDUCED BLOCK OF SKELETAL NEUROMUSCULAR-TRANSMISSION INVITRO [J].

BRAGA, MFM ;

ROWAN, EG .

BRITISH JOURNAL OF PHARMACOLOGY, 1992, 107 (01) :95-100

[4] PRE-SYNAPTIC CURRENTS IN MOUSE MOTOR ENDINGS [J].

BRIGANT, JL ;

MALLART, A .

JOURNAL OF PHYSIOLOGY-LONDON, 1982, 333 (DEC) :619-636

[5] CA2+-DEPENDENT RECYCLING OF SYNAPTIC VESICLES AT THE FROG NEUROMUSCULAR-JUNCTION [J].

CECCARELLI, B ;

HURLBUT, WP .

JOURNAL OF CELL BIOLOGY, 1980, 87 (01) :297-303

[6] EVIDENCE FOR THE INVOLVEMENT OF DITHIOL GROUPS IN MITOCHONDRIAL CALCIUM-TRANSPORT - STUDIES WITH CADMIUM [J].

CHAVEZ, E ;

BRIONES, R ;

MICHEL, B ;

BRAVO, C ;

JAY, D .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1985, 242 (02) :493-497

[7]

CHEUNG WY, 1988, ANN NY ACAD SCI, V522, P74

[8] INTERACTIONS OF LEAD AND CADMIUM ON ACETYLCHOLINE-RELEASE AT THE FROG NEUROMUSCULAR-JUNCTION [J].

COOPER, GP ;

MANALIS, RS .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1984, 74 (03) :411-416

[9] CADMIUM - EFFECTS ON TRANSMITTER RELEASE AT THE FROG NEUROMUSCULAR-JUNCTION [J].

COOPER, GP ;

MANALIS, RS .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1984, 99 (04) :251-256

[10] NEUROTOXIC CATIONS INDUCE MEMBRANE RIGIDIFICATION AND MEMBRANE-FUSION AT MICROMOLAR CONCENTRATIONS [J].

DELEERS, M ;

SERVAIS, JP ;

WULFERT, E .

BIOCHIMICA ET BIOPHYSICA ACTA, 1986, 855 (02) :271-276

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