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DIPHTHERIA TOXIN SUBUNIT ACTIVE IN VITRO

被引：75
作者：
COLLIER, RJ
COLE, HA
机构：
[1] Department of Bacteriology, University of California, Los Angeles, CA
来源：
SCIENCE | 1969年 / 164卷 / 3884期
关键词：
D O I：
10.1126/science.164.3884.1179
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Exposure of diphtheria toxin to dithiothreitol (and similar thiols) resulted in a subunit which was active in catalyzing the adenosine diphosphate-ribosylation of mammalian aminoacyl-transferase II in the presence of nicotinamide adenine dinucleotide. At the same time there was a marked increase in total ADP-ribosylation activity. A molecule which was apparently identical to the derived subunit in size and activity was detected in partially purified preparations of toxin.
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页码：1179 / &
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