N-TERMINAL PRO ATRIAL-NATRIURETIC-PEPTIDE IN HUMAN PLASMA

被引：5

作者：

BUCKLEY, MG

SAGNELLA, GA

MARKANDU, ND

SINGER, DRJ

MACGREGOR, GA

机构：

[1] The Blood Pressure Unit, Department of Medicine, Charing Cross and Westminster Medical School, London

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1990年 / 3卷 / 12期

关键词：

PRO ANP; HUMAN PLASMA; RENAL FAILURE; HYPERTENSION;

D O I：

10.1093/ajh/3.12.933

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

N-Terminal pro ANP (atrial natriuretic peptide) in human plasma has been measured by radioimmunoassay after extraction on Sep-Pak cartridges. Immunoreactive N-terminal pro ANP circulates in human plasma at higher levels than alpha-hANP (approximately 20-fold higher in normal subjects) and was elevated in patients with essential hypertension, cardiac transplantation and patients with chronic renal failure. In chronic renal failure patients undergoing hemodialysis, C-terminal ANP (ANP 99-126), but not N-terminal ANP, declined significantly after dialysis. Gel filtration experiments demonstrated a single peak of N-terminal ANP immunoreactivity, eluting in parallel with synthetic human pro ANP 1-67, indicating a similar molecular size and the absence of low molecular weight N-terminal fragments.

引用

页码：933 / 935

页数：3

共 9 条

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