METAANALYSIS OF EPIDEMIOLOGIC DOSE-RESPONSE DATA

被引：492

作者：

BERLIN, JA

LONGNECKER, MP

GREENLAND, S

机构：

[1] Center for Clinical Epidemiology and Biostatistics, University of pennysylvania School of Medicine, Philadelphia, PA

[2] Department of Epidemiology, UCLA School of Public Health, Los Angels, CA

来源：

EPIDEMIOLOGY | 1993年 / 4卷 / 03期

关键词：

METAANALYSIS; EPIDEMIOLOGIC METHODS; MODELS; EXPOSURE CATEGORIZATION; CASE-CONTROL STUDIES; BREAST NEOPLASMS;

D O I：

10.1097/00001648-199305000-00005

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

We discuss methods for summarizing epidemiologic studies of dose-response. The data from such a study typically appear as a series of dose-specific relative risks, with one category serving as the common reference group. We present methods for estimating the dose-response parameters from single and multiple study reports, for assigning levels to exposure categories when modeling relative risks, and for investigating the effects of study design and subject characteristics on dose-response curves. Finally, we discuss the choice of fixed vs random effects models. We illustrate our points with data from case-control studies of the relation between duration of oral contraceptive use and risk of breast cancer.

引用

页码：218 / 228

页数：11

共 48 条

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