SEARCH FOR CONFIGURATIONALLY STABLE, ARACEMIC ALPHA-AMINO ORGANOLITHIUMS

被引：70

作者：

GAWLEY, RE

ZHANG, QH

机构：

[1] Department of Chemistry, University of Miami, Coral Gables

来源：

TETRAHEDRON | 1994年 / 50卷 / 20期

关键词：

ALPHA-AMINO ORGANOLITHIUMS; ALPHA-AMINO CARBANIONS; 2-LITHIOPIPERIDINE; 2-LITHIOPYRROLIDINE; CONFIGURATIONALLY STABLE CARBANIONS;

D O I：

10.1016/S0040-4020(01)90459-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The search for configurationally stable alpha-amino carbanions has led to an interesting observation of differing reactivity of diastereomeric organolithiums and to the characterization of aracemic 2-lithio-N-methylpiperidine and 2-lithio-N-methylpyrrolidine as configurationally stable alpha-aminoorganolithiums. Details for the preparation of these and related alpha-lithioheterocycles, evaluation of their chemical and configurational stability, and a preliminary evaluation of the stereoselectivity of their reactions with electrophiles is presented.

引用

页码：6077 / 6088

页数：12

共 73 条

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