ACTIVE INCREASE IN CARDIOLIPIN SYNTHESIS IN THE STATIONARY GROWTH-PHASE AND ITS PHYSIOLOGICAL SIGNIFICANCE IN ESCHERICHIA-COLI

被引：91

作者：

HIRAOKA, S ^{[1
]}

MATSUZAKI, H ^{[1
]}

SHIBUYA, I ^{[1
]}

机构：

[1] SAITAMA UNIV,DEPT BIOCHEM,URAWA,SAITAMA 338,JAPAN

来源：

FEBS LETTERS | 1993年 / 336卷 / 02期

关键词：

CARDIOLIPIN; CARDIOLIPIN SYNTHASE; CELL SURVIVAL; ESCHERICHIA-COLI; STATIONARY GROWTH PHASE;

D O I：

10.1016/0014-5793(93)80807-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Activity of the Escherichia colicardiolipin synthase, encoded by cls, increased about 10-fold in the stationary growth phase, while other committed-step enzymes in phospholipid biosynthesis rather decreased. A null cls mutant lost viability to 10(-4) of the wild-type cells during the prolonged incubation for 5 days. Cardiolipin was most stable among membrane phospholipids during the incubation. Accordingly, cardiolipin should play a role in survival of the cell and E. coli employs a sophisticated way to form cardiolipin according to need even under non-growing conditions.

引用

页码：221 / 224

页数：4

共 33 条

[1] SUPPRESSION OF THE LETHAL EFFECT OF ACIDIC-PHOSPHOLIPID DEFICIENCY BY DEFECTIVE FORMATION OF THE MAJOR OUTER-MEMBRANE LIPOPROTEIN IN ESCHERICHIA-COLI [J].