CAPSAICIN-INDUCED BLADDER HYPERACTIVITY IN NORMAL CONSCIOUS RATS

被引:59
作者
ISHIZUKA, O
IGAWA, Y
MATTIASSON, A
ANDERSSON, KE
机构
[1] UNIV LUND HOSP,DEPT CLIN PHARMACOL,S-22185 LUND,SWEDEN
[2] UNIV LUND HOSP,DEPT UROL,S-22185 LUND,SWEDEN
关键词
BLADDER; CAPSAICIN; TACHYKININS; RECEPTORS-NEUROKININ-1; RECEPTORS-NEUROKININ-2;
D O I
10.1016/S0022-5347(17)32787-8
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Capsaicin, instilled intravesically in normal, unanesthetized rats induced a concentration-dependent bladder hyperactivity, which could be abolished by hexamethonium, given intraarterially near the bladder, or by morphine administered intrathecally. The effect was reversible and could be repeated. The NK-2 receptor selective antagonist SR 48,968 and the nonselective NK receptor antagonist spantide, given intra-arterially near the bladder, which by themselves, in the concentrations used, did not affect cystometric parameters, both counteracted the capsaicin-induced hyperactivity, whereas the NK-1 receptor selective antagonist RP 67,580 failed to do so. Blockade of tachykinin receptors in the urinary bladder does not seem to produce changes of the micturition reflex associated with bladder filling in the conscious rat. However, tachykinins released from capsaicin-sensitive nerves by various stimuli may, through stimulation of NK-2 receptors, lower the threshold for initiation of the micturition reflex. In the rat, intravesical capsaicin may be a suitable model for studies of afferent activity caused by stimuli releasing peptides from sensory nerves in the bladder, thereby provoking bladder hyperactivity.
引用
收藏
页码:525 / 530
页数:6
相关论文
共 38 条
[1]  
BURCHER E, 1986, J PHARMACOL EXP THER, V236, P819
[2]   MULTIPLE TACHYKININ BINDING-SITES IN HAMSTER, RAT AND GUINEA-PIG URINARY-BLADDER [J].
BURCHER, E ;
BUCK, SH .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1986, 128 (03) :165-177
[3]  
CARSTAIRS JR, 1992, NEUROPEPTIDES S, V22, P13
[4]  
CARSTAIRS JR, 1993, NEUROPEPTIDES, V24, P200
[5]   MECHANISMS UNDERLYING THE RECOVERY OF URINARY-BLADDER FUNCTION FOLLOWING SPINAL-CORD INJURY [J].
DEGROAT, WC ;
KAWATANI, M ;
HISAMITSU, T ;
CHENG, CL ;
MA, CP ;
THOR, K ;
STEERS, W ;
ROPPOLO, JR .
JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM, 1990, 30 :S71-S78
[6]   NONCHOLINERGIC INOTROPIC RESPONSES EVOKED BY ELECTRIC-FIELD STIMULATION IN THE ISOLATED RAT URINARY-BLADDER - POSSIBLE PARTICIPATION OF SUBSTANCE-P [J].
DVEKSLER, G ;
GIMENO, MF ;
GIMENO, AL .
PHARMACOLOGICAL RESEARCH COMMUNICATIONS, 1985, 17 (12) :1109-1119
[7]  
FALCONIERIERSPA.G, 1973, N-S ARCH PHARMACOL, V279, P61
[8]   INTRAVESICAL CAPSAICIN FOR NEUROGENIC BLADDER DYSFUNCTION [J].
FOWLER, CJ ;
JEWKES, D ;
MCDONALD, WI ;
LYNN, B ;
DEGROAT, WC .
LANCET, 1992, 339 (8803) :1239-1239
[9]   PHARMACOLOGICAL PROPERTIES OF A POTENT AND SELECTIVE NONPEPTIDE SUBSTANCE-P ANTAGONIST [J].
GARRET, C ;
CARRUETTE, A ;
FARDIN, V ;
MOUSSAOUI, S ;
PEYRONEL, JF ;
BLANCHARD, JC ;
LADURON, PM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (22) :10208-10212
[10]   A PHARMACOLOGICAL STUDY OF NK1-TACHYKININ AND NK2-TACHYKININ RECEPTOR CHARACTERISTICS IN THE RAT ISOLATED URINARY-BLADDER [J].
HALL, JM ;
FLOWERS, JM ;
MORTON, IKM .
BRITISH JOURNAL OF PHARMACOLOGY, 1992, 107 (03) :777-784