SPECIES VARIATION IN METABOLISM OF R-(+)-NICOTINE AND S-(-)-NICOTINE BY ALPHA-C-OXIDATION AND N-OXIDATION IN-VITRO

被引：40

作者：

JENNER, P ^{[1
]}

GORROD, JW ^{[1
]}

BECKETT, AH ^{[1
]}

机构：

[1] UNIV LONDON,CHELSEA COLL,DEPT PHARM,MANRESA RD,LONDON SW3,ENGLAND

来源：

XENOBIOTICA | 1973年 / 3卷 / 09期

关键词：

D O I：

10.3109/00498257309151545

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：573 / 580

页数：8

共 18 条

[1] CHARACTERIZATION OF DIASTEREOISOMERS OF NICOTINE-1'-N-OXIDE, A METABOLITE OF NICOTINE, AND OTHER POSSIBLE OXIDATION-PRODUCTS BY NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY [J].

BECKETT, AH ;

JENNER, P ;

GORROD, JW .

XENOBIOTICA, 1973, 3 (09) :557-562

[2] ANALYSIS OF NICOTINE-1'-N-OXIDE IN URINE, IN PRESENCE OF NICOTINE AND COTININE, AND ITS APPLICATION TO STUDY OF IN-VIVO NICOTINE METABOLISM IN MAN [J].

BECKETT, AH ;

GORROD, JW ;

JENNER, P .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1971, 23 :S55-&

[3] POSSIBLE RELATION BETWEEN PKA1 AND LIPID SOLUBILITY AND AMOUNTS EXCRETED IN URINE OF SOME TOBACCO ALKALOIDS GIVEN TO MAN [J].

BECKETT, AH ;

JENNER, P ;

GORROD, JW .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1972, 24 (02) :115-&

[4]

BECKETT AH, 1965, TETRAHEDRON LETT, P537

[5] ENZYMIC OXIDATION OF (-)-NICOTINE BY GUINEA-PIG TISSUES IN-VITRO [J].

BOOTH, J ;

BOYLAND, E .

BIOCHEMICAL PHARMACOLOGY, 1971, 20 (02) :407-&

[6] METABOLISM OF NICOTINE INTO 2 OPTICALLY-ACTIVE STEREOISOMERS OF NICOTINE-1'-OXIDE BY ANIMAL TISSUES IN-VITRO AND BY CIGARETTE SMOKERS [J].

BOOTH, J ;

BOYLAND, E .

BIOCHEMICAL PHARMACOLOGY, 1970, 19 (03) :733-&

[7]

BOOTH J, 1967, BRIT EMP CANCER CAMP, V45, P25

[8]

BOWMAN ER, 1959, BIOCHEM PREP, V10, P36

[9]

BOYLAND E, 1966, BRIT EMP CANCER CAMP, V44, P21

[10]

COCHIN J, 1959, J PHARMACOL EXP THER, V125, P105

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