IDENTIFICATION AND EVALUATION OF AMITRIPTYLINE AND ITS BASIC METABOLITES BY THIN-LAYER CHROMATOGRAPHY IN RABBIT ORGANS

被引：6

作者：

FACINO, RM

CORONA, GL

机构：

[1] University of Pavia, Cattedia di Farmacologia, Pavia

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 06期

关键词：

Amitriptyline; basic metabolites—analysis; rabbit organs; Colorimetric analysis—spectrophotometer; TLC—separation; UV light—chromatographic spot visualization;

D O I：

10.1002/jps.2600580628

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The conditions for the identification and for a quantitative evaluation, in rabbit organs, of amitriptyline and its basic metabolites (10‐hydroxyamitriptyline, 10,11‐hydroxyamitriptyline, noramitriptyline, 10‐hydroxynoramitriptyline, and 10,11‐hydroxynoramitriptyline) are reported. After a suitable purification of organ extracts a chromatographic separation of amitriptyline and its metabolites is achieved by using thin‐layer chromatography. Quantitative colorimetric analyses of metabolites are run. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：764 / &