MORPHINE-METABOLISM IN THE NATURALLY MORPHINE-TOLERANT AFGHAN PIKA - A PRELIMINARY-STUDY

被引：6

作者：

COIMBRAFARGES, R

PUGET, A

MONSARRAT, B

MOISAND, C

MEUNIER, JC

机构：

[1] Laboratoire de Pharmacologie, Toxicologie Fondamentales CNRS, 31077 Toulouse Cédex

来源：

LIFE SCIENCES | 1990年 / 46卷 / 09期

关键词：

D O I：

10.1016/0024-3205(90)90135-E

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The afghan pika (Ochotona refescens), a lagomorph which is naturally tolerant to the analgesic action of morphine, metabolizes morphine into morphine 3-glucuronide apparently faster than does the rabbit, another lagomorph which is however normally responsive to morphine. In the two species, following morphine administration, another unidentified component appears very soon (5 min) in pika blood plasma and much later (60 min) in rabbit blood plasma. This unknown component which appers not to be morphine derived might be involved in the natural resistance of the Afghan pika to morphine. © 1990.

引用

页码：663 / 669

页数：7

共 12 条

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[2]

Coimbra Farges R., 1988, Life Sciences, V43, P659, DOI 10.1016/0024-3205(88)90136-1

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