BASAL AND INDUCED PROTHROMBINASE EXPRESSION IN PLATELETS FROM PATIENTS WITH ESSENTIAL THROMBOCYTHEMIA (ET)

被引：12

作者：

CROOK, M ^{[1
]}

MACHIN, SJ ^{[1
]}

CRAWFORD, N ^{[1
]}

机构：

[1] MIDDLESEX HOSP,DEPT HAEMATOL,LONDON W1,ENGLAND

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1990年 / 76卷 / 02期

关键词：

D O I：

10.1111/j.1365-2141.1990.tb07881.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Summary Both the basal and the collagen plus thrombin‐stimulated prothrombinase activities have been measured in platelets from eight patients with essential thrombocythaemia (ET). On a mean basis these activities were significantly lower than the values recorded for a group of age and sex matched control subjects. When the Ca2+ ionophore A23187 was substituted for the agonist mixture the induced expression of prothrombinase activity was essentially the same for the patient and control groups. It is suggested that the defect in prothrombinase expression seen with ET platelets may reside in either membrane signal transduction processes concerned with Ca2+ mobilization or in Ca2+ sensitive cytoskeletal control of membrane phospholipid topography. Copyright © 1990, Wiley Blackwell. All rights reserved

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页码：256 / 259

页数：4

相关论文

共 13 条

[1] GENERATION OF PROTHROMBIN-CONVERTING ACTIVITY AND THE EXPOSURE OF PHOSPHATIDYLSERINE AT THE OUTER SURFACE OF PLATELETS [J].

BEVERS, EM ;

COMFURIUS, P ;

VANRIJN, JLML ;

HEMKER, HC ;

ZWAAL, RFA .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1982, 122 (02) :429-436

[2]

BEVERS EM, 1986, BRIT J HAEMATOL, V63, P335

[3] CHANGES IN MEMBRANE PHOSPHOLIPID DISTRIBUTION DURING PLATELET ACTIVATION [J].

BEVERS, EM ;

COMFURIUS, P ;

ZWAAL, RFA .

BIOCHIMICA ET BIOPHYSICA ACTA, 1983, 736 (01) :57-66

[4] THE INVOLVEMENT OF CYTOSKELETON IN THE REGULATION OF TRANSBILAYER MOVEMENT OF PHOSPHOLIPIDS IN HUMAN-BLOOD PLATELETS [J].

COMFURIUS, P ;

BEVERS, EM ;

ZWAAL, RFA .

BIOCHIMICA ET BIOPHYSICA ACTA, 1985, 815 (01) :143-148

[5] CHARACTERIZATION OF THE PLATELET PROSTAGLANDIN-D2 RECEPTOR - LOSS OF PROSTAGLANDIN-D2 RECEPTORS IN PLATELETS OF PATIENTS WITH MYELOPROLIFERATIVE DISORDERS [J].

COOPER, B ;

AHERN, D .

JOURNAL OF CLINICAL INVESTIGATION, 1979, 64 (02) :586-590

[6] PLATELET SURFACE-CHARGE HETEROGENEITY - CHARACTERIZATION OF HUMAN-PLATELET SUBPOPULATIONS SEPARATED BY HIGH-VOLTAGE CONTINUOUS-FLOW ELECTROPHORESIS [J].

CROOK, M ;

CRAWFORD, N .

BRITISH JOURNAL OF HAEMATOLOGY, 1988, 69 (02) :265-273

[7] HAEMORRHAGIC THROMBOCYTHAEMIA - A CLINICAL AND LABORATORY STUDY [J].

HARDISTY, RM ;

WOLFF, HH .

BRITISH JOURNAL OF HAEMATOLOGY, 1955, 1 (04) :390-405

[8]

KAWIN P, 1978, NEW ENGL J MED, V299, P505

[9] PLATELET MEMBRANE ABNORMALITIES IN MYELOPROLIFERATIVE DISORDERS - DECREASE IN GLYCOPROTEIN-IB AND GLYCOPROTEIN-IIB IIIA COMPLEX IS ASSOCIATED WITH DEFICIENT RECEPTOR FUNCTION [J].

MAZZUCATO, M ;

DEMARCO, L ;

DEANGELIS, V ;

DEROIA, D ;

BIZZARO, N ;

CASONATO, A .

BRITISH JOURNAL OF HAEMATOLOGY, 1989, 73 (03) :369-374

[10] PLATELET FUNCTION TESTS IN THROMBOCYTHAEMIA AND THROMBOCYTOSIS [J].

MCCLURE, PD ;

INGRAM, GIC ;

STACEY, RS ;

GLASS, UH ;

MATCHETT, MO .

BRITISH JOURNAL OF HAEMATOLOGY, 1966, 12 (04) :478-&