PHYSIOLOGICAL-FUNCTION OF DESCENDING NORADRENALINE PROJECTIONS TO THE SPINAL-CORD - ROLE IN POST-DECAPITATION CONVULSIONS

Destruction of the descending noradrenergic innervation to the spinal cord, but not that to the cerebellum or the forebrain, by the use of intracerebral injection of 6-hydroxydopamine completely prevented the occurrence of the usual decapitation convulsion. Depletion of brain noradrenaline by synthesis inhibition with DDC, FLA 57 or FLA 63 g reduced the duration of the post-decapitation convulsion. Blockade of α-noradrenergic receptors by phentolamine or phenoxybenzamine, but not of β-receptors by propranolol, also reduced the duration of the convulsion. The presynaptic α-agonist, clonidine, at either 1 mg/kg or 0.05 mg/kg also reduced the magnitude of the convulsion but either blockade of dopamine receptors with pimozide or destruction of the ascending dopamine systems by 6-hydroxydopamine was without effect. It is concluded that dopamine systems are not involved in post-decapitation convulsions and that the noradrenergic involvement is by the descending spinal projections acting on a post-synaptic α-receptor in the spinal cord, but also modulated by presynaptic α-receptors possibly on the locus coeruleus perikarya. © 1979.