A NEW APPROACH FOR THE FILTRATE REGENERATION SYSTEM IN THE WEARABLE ARTIFICIAL-KIDNEY

被引：6

作者：

TADA, Y ^{[1
]}

HORIUCHI, T ^{[1
]}

OHTA, Y ^{[1
]}

DOHI, T ^{[1
]}

机构：

[1] UNIV TOKYO,FAC ENGN,DEPT PRECIS MACHINERY ENGN,7-3-1 HONGO,BUNKYO KU,TOKYO 113,JAPAN

来源：

ARTIFICIAL ORGANS | 1990年 / 14卷 / 06期

关键词：

Ammonium adsorption; Charged membrane; Filtrate regeneration; Ion‐exchanger; Wearable artificial kidney;

D O I：

10.1111/j.1525-1594.1990.tb02994.x

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Abstract: In the filtrate and/or dialysate regeneration system, which is expected to miniaturize the artificial kidney, ammonium decomposed from urea by immobilized urease is removed competitively by ion‐exchangers from coexisting cations. Since divalent cations such as Ca2+ and Mg2+ are more favorably exchanged than ammonium ion, this system needs supplementation of these cations and, thus, additional amount of ion‐exchanger. To minimize these requirements, we utilized positively charged membrane to process cation‐free filtrate in which urea is dialyzed. Positively charged membranes were tested in vitro to evaluate separation efficiency between urea and cations. Equilibrium adsorption of ammonium ion to ion‐exchanger with or without co‐existing cations demonstrates that this filtrate regeneration system can reduce the amount of ion‐exchanger up to one‐half to one‐third of that of the conventional system. In an ex vivo experiment with a mongrel dog, blood urea nitrogen (BUN) concentration was maintained at the same level or up to 23% less than the initial value. © 1990 International Society for Artificial Organs

引用

页码：405 / 409

页数：5

共 12 条

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[5]

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