SEQUENCES OF THE BOTULINAL NEUROTOXIN-E DERIVED FROM CLOSTRIDIUM-BOTULINUM TYPE-E (STRAIN-BELUGA) AND CLOSTRIDIUM-BUTYRICUM (STRAINS ATCC-43181 AND ATCC-43755)

被引：84

作者：

POULET, S

HAUSER, D

QUANZ, M

NIEMANN, H

POPOFF, MR

机构：

[1] INST PASTEUR,UNITE ANTIGENES BACTERIENS,25 RUE DOCTEUR ROUX,F-75724 PARIS 15,FRANCE

[2] FED RES CTR VIRUS DIS ANIM,W-7400 TUBINGEN,GERMANY

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 183卷 / 01期

关键词：

D O I：

10.1016/0006-291X(92)91615-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recently, it has been shown that two Clostridium butyricum strains (ATCC 43181 and ATCC 43755), isolated from cases of infant botulism, produce a botulinal neurotoxin type E ( BoNT E). Here we have determined the nucleotide sequences of the BoNT E genes of these two C. butyricum strains and from C. botulinum E strain Beluga. We show that the sequences of the BoNT E genes from the two C. butyricum strains are identical and differ in only 64 positions resulting in 39 amino acid changes (97% identity at the amino acid level) from that derived from C. botulinum. Our data suggest a transfer of the BoNT E gene from C. botulinum to the originally nontoxigenic C. butyricum strains. © 1992.

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页码：107 / 113

页数：7

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