SEQUENTIAL ASSIGNMENT OF 2D-NMR SPECTRA OF PROTEINS USING GENETIC ALGORITHMS

被引：23

作者：

WEHRENS, R

LUCASIUS, C

BUYDENS, L

KATEMAN, G

机构：

[1] Laboratory for Analytical Chemistry, Catholic University of Nijmegen, 6525 ED Nijmegen

来源：

JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES | 1993年 / 33卷 / 02期

关键词：

D O I：

10.1021/ci00012a010

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The application of genetic algorithms to the problem of the sequential assignment of two-dimensional protein NMR spectra is discussed. The problem is heavily underconstrained since in most cases more patterns are available than amino acid positions, and uncertainties may exist in the preliminary assignments. The results indicate that relatively large amounts of errors may be present in the input data for the genetic algorithm while useful results may still be obtained.

引用

页码：245 / 251

页数：7

共 14 条

[1] PEPTO - AN EXPERT SYSTEM FOR AUTOMATIC PEAK ASSIGNMENT OF 2-DIMENSIONAL NUCLEAR-MAGNETIC-RESONANCE SPECTRA OF PROTEINS [J].

CATASTI, P ;

CARRARA, E ;

NICOLINI, C .

JOURNAL OF COMPUTATIONAL CHEMISTRY, 1990, 11 (07) :805-818

[2] RUBIDIUM, A PROGRAM FOR COMPUTER-AIDED ASSIGNMENT OF 2-DIMENSIONAL NMR-SPECTRA OF POLYPEPTIDES [J].

CHIN, Y ;

HWANG, JF ;

CHEN, TB ;

SOO, VW .

JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES, 1992, 32 (03) :183-187

[3] COMPUTER-AIDED SEQUENTIAL ASSIGNMENT OF PROTEIN H-1-NMR SPECTRA [J].

CIESLAR, C ;

CLORE, GM ;

GRONENBORN, AM .

JOURNAL OF MAGNETIC RESONANCE, 1988, 80 (01) :119-127

[4]

Davis L., 1991, HDB GENETIC ALGORITH

[5] PROGRAMS FOR COMPUTER-ASSISTED SEQUENTIAL ASSIGNMENT OF PROTEINS [J].

EADS, CD ;

KUNTZ, ID .

JOURNAL OF MAGNETIC RESONANCE, 1989, 82 (03) :467-482

[6]

Holland J., 1989, GENETIC ALGORITHMS S

[7] TOWARD AUTOMATIC ASSIGNMENT OF PROTEIN H-1-NMR SPECTRA [J].

KLEYWEGT, GJ ;

LAMERICHS, RMJN ;

BOELENS, R ;

KAPTEIN, R .

JOURNAL OF MAGNETIC RESONANCE, 1989, 85 (01) :186-197

[8]

LUCASIUS CB, 1992, 2ND P WORKSH PAR PRO, P239

[9]

LUCASIUS CB, 1993, UNPUB CHEMOMETRIC IN

[10]

LUCASIUS CB, 1991, GATES GENETIC ALGORI

← 1 2 →