LYSYL OXIDASE COPPER-TALON COMPLEX - A MODEL

被引：36

作者：

KREBS, CJ

KRAWETZ, SA

机构：

[1] WAYNE STATE UNIV,SCH MED,DEPT MOLEC BIOL & GENET,253 CS MOTT CTR HUMAN GROWTH & DEV,DETROIT,MI 48201

[2] WAYNE STATE UNIV,SCH MED,DEPT OBSTET & GYNECOL,DETROIT,MI 48201

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1202卷 / 01期

关键词：

LYSYL OXIDASE; AMINO ACID SEQUENCE; ENZYME MODEL; PROTEIN STRUCTURE; CDNA CLONING;

D O I：

10.1016/0167-4838(93)90056-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The translated primary amino-acid sequences from human genomic and human, rat and mouse lysyl oxidase cDNAs were subjected to computer comparison. This revealed a highly-conserved primary structure and similar computer-predicted secondary structures. A prototypical lysyl oxidase structural model was reconciled with the known physical, chemical and biological properties. Analysis of the post-translationally-modified and proteolytically-processed mature enzyme model revealed a copper coordination complex that may be contained as part of the active site. This integral copper coordination complex resembles a talon. The proposed model should facilitate the elucidation of these and other structural and functional relationships within the lysyl oxidase molecule.

引用

页码：7 / 12

页数：6

共 27 条

[1]

ARGOS P, 1982, EUR J BIOCHEM, V128, P565

[2]

BLACK SD, 1986, BIOTECHNIQUES, V4, P448

[3] EMPIRICAL PREDICTIONS OF PROTEIN CONFORMATION [J].