EVALUATION OF A NEW EMBRYO-GRADING SYSTEM TO PREDICT PREGNANCY RATES FOLLOWING IN-VITRO FERTILIZATION

被引：24

作者：

HOOVER, L

BAKER, A

CHECK, JH

LURIE, D

OSHAUGHNESSY, A

机构：

[1] UNIV MED & DENT NEW JERSEY,COOPER HOSP,ROBERT WOOD JOHNSON MED SCH,MED CTR,DEPT OBSTET & GYNECOL,CAMDEN,NJ 08103

[2] UNIV MED & DENT NEW JERSEY,COOPER HOSP,ROBERT WOOD JOHNSON MED SCH,MED CTR,CAMDEN,NJ 08103

来源：

GYNECOLOGIC AND OBSTETRIC INVESTIGATION | 1995年 / 40卷 / 03期

关键词：

EMBRYO MORPHOLOGY; HUMAN IN VITRO FERTILIZATION; IMPLANTATION; IN VITRO FERTILIZATION; MULTIPLE PREGNANCY; FREQUENCY; PREIMPLANTATION DEVELOPMENT;

D O I：

10.1159/000292326

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

This study examines two descriptive parameters of embryo morphology to determine if either parameter correlates with subsequent pregnancy rates (PRs). The two parameters were the evenness (similarity in size) of the blastomeres and the degree of cellular fragmentation. A total of 242 embryo transfers in which 4 embryos were transferred were included. Sixty-nine (28.5%) clinical and 62 (25.6%) viable pregnancies resulted. In all cases 4 embryos were transferred, but the number of embryos with even round blastomeres (grade 1) varied from 0 to 4. Statistically, there was no correlation between PR and number of grade 1 embryos transferred. When 4 grade 1 embryos were transferred, the PR was 33.3 versus 28.1% when no grade 1 embryos were transferred. There was, however, a statistical difference in the implantation rate; a higher frequency of multiple gestations occurred when 3 or 4 of the embryos transferred were graded 1:12.7 as compared with 6.7% when less than or equal to 2 embryos were grade 1. The significance of the degree of cellular fragmentation in the embryos was also assessed. There was no statistical difference in the PR according to the number (0-4) of embryos transferred that did not have fragments (grade A). When 4 grade A embryos were transferred, the PR was 18.2 versus 26.1% when there were no grade A embryos. Neither implantation nor multiple-birth rates correlated with fragmentation.

引用

页码：151 / 157

页数：7

共 13 条

[1]

Winston N.J., Braude P.R., Pickering S.J., George M.A., Cant A., Currie J., Johnson M.H., The incidence of abnormal morphology and nucleocy- toplasmic ratios in 2-, 3-, and 5-day human preembryos, Hum Reprod, 1, pp. 17-24, (1991)

[2]

Erenus M., Leung S., Zouves C., Fluker M., Raja-Mahendran P., Gomel V., The effect of embryo quality on subsequent pregnancy rates after in vitro fertilization, Fertil Steril, 56, pp. 707-710, (1991)

[3]

Steer C.V., Mills C.L., Tan S.L., Campbell S., Edwards R.G., The cumulative embryo score: A predictive embryo scoring technique to select the optimal number of embryos to transfer in an in-vitro fertilization and embryo transfer programme, Hum Reprod, 7, pp. 117-119, (1992)

[4]

Bolton V.N., Hawes S.M., Taylor C.T., Parsons J.H., Development of spare human preimplan- tation embryos in vitro: An analysis of the correlations among gross morphology, cleavage rates, and development to the blastocyst, J In Vitro Fertil Embryo Transfer, 6, pp. 30-35, (1989)

[5]

Scott R.T., Jones H., Hofmann G.E., Muasher S.J., Veeck L.L., Embryo quality and pregnancy rates in patients attempting pregnancy through in vitro fertilization, Fertil Steril, 44, pp. 426-428, (1991)

[6]

Grillo J.M., Gamcrrc M., Lacroix O., Noizet A., Vitrv G., Influence of the morphological aspect of embryos obtained by in vitro fertilization on their implantation rate, J In Vitro Fertil Embryo T ransfer, 8, pp. 317-321, (1991)

[7]

Shulman A., Kaneti H., Bcn-Nun I., Shilon M., Ghetler Y., Beyth Y., Relationship between embryo moφhology and implantation rate after in vitro fertilization treatment in conception cycles, Fertil Steril, 60, pp. 123-126, (1993)

[8]

Staessen C., Devroev P., Camus M., Van Steir- teghem A.C., Bollen N., The relationship between embryo quality and the occurrence of multiple pregnancies, Fertil Steril, 57, pp. 626-630, (1992)

[9]

Mcldrum D.R., Gutlav A.L., Wisot A., Kempton W., Hamilton F., Huynh D., Routine pituitary suppression with leuprolidc before ovarian stimulation for oocyte retrieval, Fertil Steril, 51, pp. 455-459, (1989)

[10]

Garcia J.E., Padilla S.L., Bayati J., Baramki T.A., Follicular phase gonadotropin-releasing hormone agonist and human gonadotropins: A better alternative for ovulation induction in in vitro fertilization, Fertil Steril, 53, pp. 302-305, (1990)

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