DIRECT MEASUREMENT OF THE TRANSPORT-PROPERTIES OF A SINGLE DNA MOLECULE

被引：93

作者：

WIRTZ, D

机构：

[1] Department of Chemical Engineering, Johns Hopkins University, Baltimore, MD 21218

来源：

PHYSICAL REVIEW LETTERS | 1995年 / 75卷 / 12期

关键词：

D O I：

10.1103/PhysRevLett.75.2436

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

A fluorescently labeled DNA molecule is end tethered to a small magnetic bead and pulled by a calibrated magnetic force through a solution of unlabeled DNA molecules to monitor the transport coefficients of the chain. From the force velocity diagram F-V, we report the first direct measurement of the friction coefficient zeta = F/V of a single DNA molecule. zeta is found to be highly velocity dependent due to sharp conformational transitions for increasing velocities in agreement with a recent model by Ajdari et al.

引用

页码：2436 / 2439

页数：4

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