CYTOKINES IN RHEUMATOID-ARTHRITIS

被引：22

作者：

HOUSSIAU, FA

机构：

[1] Rheumatology Unit, UCL 5390, Bruxelles, B-1200

来源：

CLINICAL RHEUMATOLOGY | 1995年 / 14卷

关键词：

CYTOKINES; RHEUMATOID ARTHRITIS; T CELLS;

D O I：

10.1007/BF02215851

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An ever-growing number of cytokines that play a critical role as soluble mediators of immune and inflammatory responses are being described. Not surprisingly, most of them have been detected in SF or serum of patients with RA. However, given the numerous interactions within the cytokine network - e.g. agonistic and antagonistic properties and natural inhibitors - one should beware of over-simplistic views, the more so as extrapolation from in vitro and animal models is always a challenge. From a clinical viewpoint, more work is required before measurements of cytokines in RA be used as activity indices and - more importantly - as prognostic markers.

引用

页码：10 / 13

页数：4

共 21 条

[1]

Miossec P., Cytokine abnormalities in inflammatory arthritis, Baillière's Clinical Rheumatology, pp. 373-392, (1992)

[2]

Houssiau F.A., Devogelaer J.-P., Van Damme J., Nagant de Deuxchaisnes C., Van Snick J., Interleukin 6, in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides, Arthritis Rheum, 31, pp. 784-788, (1988)

[3]

Stimpson S.A., Dalldorf F.G., Otterness I.G., Schwab J.H., Exacerbation of arthritis by IL-1 in rat joints previously injured by peptidoglycan-polysaccharide, J Immunol, 140, pp. 2964-2969, (1988)

[4]

di Giovine F.S., Duff G.W., Interleukin 1: the first interleukin, Immunol Today, 11, pp. 13-20, (1990)

[5]

Eisenberg S.P., Evans R.J., Arend W.P., Verderber E., Brewer M.T., Hannum C.H., Thompson R.C., Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist, Nature, 343, pp. 341-346, (1990)

[6]

Malyak M., Swaney R.E., Arend W.P., Levels of synovial fluid interleukin-1 receptor antagonist in rheumatoid arthritis and other arthropathies, Arthritis Rheum, 36, pp. 781-789, (1993)

[7]

Saxne T., Palladino M.A., Heinegard D., Talal N., Wollheim F.A., Detection of tumor necrosis factor α but not tumor necrosis β in rheumatoid arthritis synovial fluid and serum, Arthritis & Rheumatism, 31, pp. 1041-1045, (1988)

[8]

Keffer J., Probert L., Cazlaris H., Georgopoulos S., Kaslaris E., Kioussis D., Kollias G., Transgenic mice expressing human tumour necrosis α: a predictive genetic model of arthritis, EMBO J, 10, pp. 4025-4031, (1991)

[9]

Seckinger P., Zhang J.H., Hauptmann B., Characterization of a tumor necrosis factor α (TNF-α) inhibitor: evidence of immunological cross-reactivity with the TNF receptor, Proc Natl Acad Sci USA, 87, pp. 5188-5192, (1990)

[10]

Lotz M., Guerne P.-A., Interleukin-6 induces the synthesis of tissue inhibitor of metalloproteinases-1/erythroid potentiating activity (TIMP-1/EPA), J Biol Chem, 266, pp. 2017-2020, (1991)

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