ERYTHROCYTE-MEMBRANE PHOSPHOLIPIDS IN PSYCHOTIC-PATIENTS

被引：75

作者：

KESHAVAN, MS

MALLINGER, AG

PETTEGREW, JW

DIPPOLD, C

机构：

[1] Matcheri S. Keshavan, M.D., is Associate Professor of Psychiatry Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA

[2] Alan G. Mallinger, M.D., is Associate Professor of Psychiatry and Pharmacology, Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA

[3] Jay W. Pettegrew, M.D., is Professor of Psychiatry and Neurology, Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA

来源：

PSYCHIATRY RESEARCH | 1993年 / 49卷 / 01期

关键词：

SCHIZOPHRENIA; SCHIZOAFFECTIVE DISORDER; PHOSPHATIDYLETHANOLAMINE; SPHINGOMYELIN;

D O I：

10.1016/0165-1781(93)90032-C

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Thin layer chromatography and laser densitometry were used to examine erythrocyte membrane phospholipid composition in 13 medication-free patients with schizophrenia or schizoaffective disorder and 11 healthy control subjects. The patient group had significantly decreased levers of phosphatidylethanolamine and a significant increase in sphingomyelin. The patient group also showed a trend toward decreased levels of phosphatidylinositol bisphosphate. Levels of phosphatidylcholine and lysophosphatidylcholine did not significantly differ between groups. There were no significant effects of age, body mass index, or gender on any of the phospholipid parameters. The observed alterations may point to abnormalities in key membrane-related functions, including signal transduction and ion transport.

引用

页码：89 / 95

页数：7

共 28 条

[1] THE MOLECULAR-BASIS OF COMMUNICATION WITHIN THE CELL [J].

BERRIDGE, MJ .

SCIENTIFIC AMERICAN, 1985, 253 (04) :142-&

[2] INCREASED PLASMA PHOSPHOLIPASE-A2 ACTIVITY IN SCHIZOPHRENIC-PATIENTS - REDUCTION AFTER NEUROLEPTIC THERAPY [J].

GATTAZ, WF ;

KOLLISCH, M ;

THUREN, T ;

VIRTANEN, JA ;

KINNUNEN, PKJ .

BIOLOGICAL PSYCHIATRY, 1987, 22 (04) :421-426

[3]

GATTAZ WF, 1990, BIOL PSYCHIAT, V28, P495

[4]

HANNUN YA, 1989, SCIENCE, V243, P300

[5]

HENN FA, 1980, PERSPECTIVES SCHIZOP, P209

[6] CHARACTERISTICS OF PHOSPHOLIPID METHYLATION IN HUMAN-ERYTHROCYTE GHOSTS - RELATIONSHIP(S) TO THE PSYCHOSES AND AFFECTIVE-DISORDERS [J].

HITZEMANN, R ;

MARK, C ;

HIRSCHOWITZ, J ;

GARVER, D .

BIOLOGICAL PSYCHIATRY, 1985, 20 (04) :397-407

[7]

Hitzemann R. J., 1982, PSYCHOPHARMACOL B, V18, P190

[8]

KAIYA H, 1984, FOLIA PSYCHIAT NEU J, V38, P437

[9] RED-CELL PHOSPHOLIPIDS IN SCHIZOPHRENIA [J].

LAUTIN, A ;

CORDASCO, DM ;

SEGARNICK, DJ ;

WOOD, L ;

MASON, MF ;

WOLKIN, A ;

ROTROSEN, J .

LIFE SCIENCES, 1982, 31 (26) :3051-3056

[10] SPHINGOMYELINASE FIBROBLAST ACTIVITY AND PSYCHOACTIVE-DRUGS [J].

LEJOYEUX, M ;

MAZIERE, JC ;

MORA, L ;

AUCLAIR, M ;

MAZIERE, C .

BIOLOGICAL PSYCHIATRY, 1991, 30 (08) :841-843

← 1 2 3 →