CLONING OF A NOVEL PUTATIVE PROTEIN-KINASE HAVING A LEUCINE-ZIPPER DOMAIN FROM HUMAN BRAIN

被引:40
作者
REDDY, UR [1 ]
PLEASURE, D [1 ]
机构
[1] UNIV PENN,CHILDRENS HOSP PHILADELPHIA,DEPT PEDIAT,PHILADELPHIA,PA 19104
关键词
D O I
10.1006/bbrc.1994.1972
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We report a novel putative serine/threonine protein kinase containing a leucine-zipper domain, isolated from an human neuronal cell line. The teratocarcinoma cell line NT2 was differentiated to postmitotic NT2-N neurons by treatment with retinoic acid, and degenerate oligonucleotide primers to the catalytic domains of protein kinases were employed to PCR amplify subtractive cDNAs. We identified a clone, represented at higher abundance in NT2-N neurons than in the parental cell line, which encodes a putative serine/threonine kinase of 668 aminoacids, the leucine-zipper protein kinase (zpk). Zpk protein contains a leucine-zipper domain, found in many DNA-binding proteins, but few protein kinases. Steady-state mRNA levels for zpk are high in human brain and kidney. Further studies are required to evaluate the role of zpk in neuronal differentiation. (C) 1994 Academic Press, Inc.
引用
收藏
页码:613 / 620
页数:8
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