beta-Amyloid selectively augments NMDA receptor-mediated synaptic transmission in rat hippocampus

被引：110

作者：

Wu, JQ

Anwyl, R

Rowan, MJ

机构：

[1] TRINITY COLL DUBLIN,DEPT PHARMACOL & THERAPEUT,DUBLIN 2,IRELAND

[2] TRINITY COLL DUBLIN,DEPT PHYSIOL,DUBLIN 2,IRELAND

来源：

NEUROREPORT | 1995年 / 6卷 / 17期

基金：

英国惠康基金;

关键词：

beta-amyloid; glutamate; N-methyl-D-aspartate (NMDA) receptor; excitatory synaptic transmission; hippocampus; dentate granule cell; Alzheimer's disease;

D O I：

10.1097/00001756-199511270-00031

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE effect of beta-amyloid on alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptor-mediated glutamatergic excitatory postsynaptic currents measured with whole-cell voltage-clamp techniques, was investigated in the rat dentate gyrus in vitro. Application of beta-amyloid (1-40) by extracellular perfusion (200nM) or intracellularly via the recording pipette (100nM) resulted in a gradual enhancement of the NMDA receptor-mediated synaptic currents which did not reverse on washout. Basal AMPA receptor-mediated transmission, resting membrane potential or input resistance of the granule cells did not change. These results provide direct evidence that beta-amyloid selectively interacts with the potentially neurotoxic NMDA receptor via a postsynaptic site. It is proposed that this action may help explain the synaptic changes seen in Alzheimer's disease.

引用

页码：2409 / 2413

页数：5

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