FACTORS WHICH MAY INFLUENCE EFFECTIVENESS OF L-ASPARAGINASES AS TUMOR INHIBITORS

Three factors are described which may be related to the greater effectiveness of the inducible E. coli asparaginase in inhibiting mouse tumors than agouti serum enzyme: first, a high avidity which enables the enzyme to retain strong activity at concentrations of asparagine found physiologically; secondly, the maintenance of low blood asparagine level for a period after removal of enzyme from the blood, and thirdly, a considerable slowing in the rate of clearance of enzyme from the blood of animals implanted with lymphoma cells. © 1968, The British Empire Cancer Campaign for Research. All rights reserved.