SYNTHESIS AND BIOLOGICAL-ACTIVITY OF THE 4 STEREOISOMERS OF 6-[4-[3-[[2-HYDROXY-3-[4-[2-(CYCLOPROPYLMETHOXY)ETHYL]PHENOXY]PROPYL]AMINO]-PROPIONAMIDO]PHENYL]-5-METHYL-4,5-DIHYDRO-3(2H)-PYRIDAZINONE, A COMBINED VASODILATOR AND BETA-ADRENOCEPTOR ANTAGONIST

被引：10

作者：

HOWSON, W

KITTERINGHAM, J

MISTRY, J

MITCHELL, MB

NOVELLI, R

SLATER, RA

SWAYNE, GTG

机构：

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1988年 / 31卷 / 02期

关键词：

D O I：

10.1021/jm00397a014

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：352 / 356

页数：5

共 16 条

[1]

BAER E, 1952, BIOCHEM PREPARAT, V2, P31

[2] BETA-ADRENERGIC BLOCKING-AGENTS WITH ACUTE ANTIHYPERTENSIVE ACTIVITY [J].

BALDWIN, JJ ;

ENGELHARDT, EL ;

HIRSCHMANN, R ;

LUNDELL, GF ;

PONTICELLO, GS ;

LUDDEN, CT ;

SWEET, CS ;

SCRIABINE, A ;

SHARE, NN ;

HALL, R .

JOURNAL OF MEDICINAL CHEMISTRY, 1979, 22 (06) :687-694

[3]

BALDWIN JJ, 1984, Patent No. 2130585

[4] 6-PHENYL-4,5-DIHYDRO-3(H-2)-PYRIDAZINONES - SERIES OF HYPOTENSIVE AGENTS [J].

CURRAN, WV ;

ROSS, A .

JOURNAL OF MEDICINAL CHEMISTRY, 1974, 17 (03) :273-281

[5]

DENNIS RA, 1984, Patent No. 2127020

[6]

Edward J, 1982, 1-(Substituted-aminoalkoxy-phenyl)-2-methylene-1-alkanones, compositions and their use, Patent No. [US 4342782, 4342782]

[7] BETA-1-SELECTIVE ADRENOCEPTOR ANTAGONISTS .1. SYNTHESIS AND BETA-ADRENERGIC BLOCKING ACTIVITY OF A SERIES OF BINARY (ARYLOXY)PROPANOLAMINES [J].

KIERSTEAD, RW ;

FARAONE, A ;

MENNONA, F ;

MULLIN, J ;

GUTHRIE, RW ;

CROWLEY, H ;

SIMKO, B ;

BLABER, LC .

JOURNAL OF MEDICINAL CHEMISTRY, 1983, 26 (11) :1561-1569

[8]

KOWALSKI C, IN PRESS SYNTHETIC A

[9] SYNTHESIS AND ANTIARRHYTHMIC ACTIVITY OF NEW 1-[1-[2-[3-(ALKYLAMINO)-2-HYDROXYPROPOXY]PHENYL]VINYL]-1H-IMIDAZOLES AND RELATED-COMPOUNDS [J].

OGATA, M ;

MATSUMOTO, H ;

TAKAHASHI, K ;

SHIMIZU, S ;

KIDA, S ;

UEDA, M ;

KIMOTO, S ;

HARUNA, M .

JOURNAL OF MEDICINAL CHEMISTRY, 1984, 27 (09) :1142-1149

[10] BROAD-SPECTRUM RESOLUTION OF OPTICAL ISOMERS USING CHIRAL HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC BONDED PHASES [J].

PIRKLE, WH ;

HOUSE, DW ;

FINN, JM .

JOURNAL OF CHROMATOGRAPHY, 1980, 192 (01) :143-158

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