INSOMNIA FOLLOWING PARACHLOROPHENYLALANIN IN RAT

被引:133
作者
MOURET, J
BOBILLIER, P
JOUVET, M
机构
[1] Laboratoire de Pathologie Expérimentale, Faculté de Médecine, Lyon
关键词
5-HT synthesis; NA-DA slow wave sleep; p-chlorophenylalanin; paradoxical sleep; Rat brain; Sleep states; Synthesis-inhibition;
D O I
10.1016/0014-2999(68)90151-9
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Intraperitoneal injection of 500 mg/kg of parachlorophenylalanin is followed by a significant decrease of both slow wave sleep and paradoxical sleep in the rat (as measured by continuous polygraphic recordings). There is a significant correlation between the decrease of cerebral serotonin, the decrease of slow wave sleep and the decrease of the rate of occurrence of paradoxical sleep. © 1993.
引用
收藏
页码:17 / +
页数:1
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