INHIBITION OF CARTILAGE MATRIX PRODUCTION BY GLUTAMYLAMINOACETONITRILE IN VITRO

被引：7

作者：

MCCALLUM, HM

ARBUTHNOTT, JP

机构：

[1] Department of Pathology, Royal Beatson Memorial Hospital, Glasgow, Scotland

[2] Department of Microbiology, The University, Glasgow, Scotland

来源：

EXPERIMENTAL AND MOLECULAR PATHOLOGY | 1969年 / 11卷 / 02期

关键词：

D O I：

10.1016/0014-4800(69)90011-2

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

A compound having a unique action on growing cartilage is described. This in glutamylamino-acetonitrile (GAAN). It is shown to produce its effect by acting as a competitive inhibitor of glutamine in the formation of glucosamine-6-phosphate and thus of cartilage matrix. It differs from other known glutamine inhibitors in that it does not prevent mitosis. © 1969.

引用

页码：232 / +

页数：1

共 14 条

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