SPECIES-DIFFERENCE AMONG EXPERIMENTAL RODENTS IN THE ACTIVITY AND INDUCTION OF CYTOCHROME-P-450 ISOZYMES FOR MUTAGENIC ACTIVATION OF CARCINOGENIC AROMATIC-AMINES

被引：11

作者：

DEGAWA, M ^{[1
]}

AGATSUMA, T ^{[1
]}

HASHIMOTO, Y ^{[1
]}

机构：

[1] TOHOKU UNIV,INST PHARMACEUT,DEPT HYG CHEM,SENDAI,MIYAGI 980,JAPAN

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1990年 / 81卷 / 12期

关键词：

CYTOCHROME-P-450; HEPATOCARCINOGENS; MUTAGENICITY; AROMATIC AMINES; RODENTS;

D O I：

10.1111/j.1349-7006.1990.tb02687.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The expressions of hepatic microsomal cytochrome P-450 isozymes in male rats, mice, hamsters and guinea pigs were studied comparatively with or without an ip injection of a cytochrome P-450 inducer. The activity and quantity of microsomal cytochrome P-450 isozymes were determined respectively by a bacterial mutation assay with Salmonella typhimurium TA98 and immunochemical assays using monoclonal antibodies against rat cytochrome P-450 isozymes. 3-Methoxy-4-aminoazobenzene (3-MeO-AAB), 2-amino-3-methyl-9H-pyrido[2,3-b]indole acetate (MeA-alpha-C) and 3-methylcholanthrene were used as cytochrome P-450 inducers, and 7 carcinogenic aromatic amines including 3-MeO-AAB and MeA-alpha-C were used as substrates for the mutation assay. By means of these assays, we examined the species differences among rodents in the activity and induction rate of hepatic cytochrome P-450 isozymes responsible for the mutagenic activation of carcinogenic aromatic amines.

引用

页码：1253 / 1258

页数：6

共 22 条

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