METHYLATION-DEPENDENT AND METHYLATION-INDEPENDENT DNA-BINDING OF NUCLEAR FACTOR EF-C

被引：11

作者：

GARCIA, AD ^{[1
]}

OSTAPCHUK, P ^{[1
]}

HEARING, P ^{[1
]}

机构：

[1] SUNY STONY BROOK,HLTH SCI CTR,DEPT MICROBIOL,STONY BROOK,NY 11794

来源：

VIROLOGY | 1991年 / 182卷 / 02期

关键词：

D O I：

10.1016/0042-6822(91)90629-P

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Nuclear factor EF-C binds to important functional sites in the hepatitis B virus and polyomavirus enhancer regions. In this paper, we have characterized new and divergent EF-C binding sites in several viral regulatory regions. We also have demonstrated that EF-C binds to certain DNA sites only when CpG dinucleotide base pairs are methylated (m5C). EF-C binds to other sites in a methylation-independent manner. Based on similar binding properties and identical binding sites, it is very likely that EF-C corresponds to the nuclear protein MDBP previously identified by virtue of binding to methylated DNA. © 1991.

引用

页码：857 / 860

页数：4

共 15 条

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