NUCLEOLAR AND CYTOPLASMIC LOCALIZATION OF ANNEXIN-V

被引：43

作者：

SUN, J ^{[1
]}

SALEM, HH ^{[1
]}

BIRD, P ^{[1
]}

机构：

[1] BOX HILL HOSP,MONASH MED SCH,CLIVE WARD CTR,DEPT MED,BOX HILL 3128,AUSTRALIA

来源：

FEBS LETTERS | 1992年 / 314卷 / 03期

关键词：

ANNEXIN V; NUCLEOLUS; ENDOTHELIAL CELL;

D O I：

10.1016/0014-5793(92)81519-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The subcellular localization of annexin V in cultured human umbilical vein endothelial cells, epithelial cells and fibroblasts was examined. Indirect immunofluorescence and immunoblotting studies using affinity-purified anti-annexin V antibodies revealed that annexin V is located within the cytoplasm and nucleus of these cells. Further examination and direct binding studies showed that annexin V within the nucleus is associated with the nucleolus. These findings suggest that annexin V may play a role in a nucleolar function, such as ribosome assembly and transport.

引用

页码：425 / 429

页数：5

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