AGE-RELATED-CHANGES OF MOTOR EVOKED-POTENTIALS IN HEALTHY HUMANS - NONINVASIVE EVALUATION OF CENTRAL AND PERIPHERAL MOTOR TRACTS EXCITABILITY AND CONDUCTIVITY

被引：129

作者：

ROSSINI, PM ^{[1
]}

DESIATO, MT ^{[1
]}

CARAMIA, MD ^{[1
]}

机构：

[1] OSPED FATEBENEFRATELLI OFTALMICO,DIV NEUROL,ROME,ITALY

来源：

BRAIN RESEARCH | 1992年 / 593卷 / 01期

关键词：

BRAIN AGING; CORTICAL EXCITABILITY; SPINAL EXCITABILITY; MAGNETIC STIMULATION; MOTOR SYSTEM;

D O I：

10.1016/0006-8993(92)91256-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A comparative analysis of the corticospinal tract nervous propagation and excitability threshold was carried out in young (25 subjects, age range 16-35 years) and in elderly (40 subjects, 51-86 years) populations of healthy volunteers. Motor evoked potentials (MEPs) were recorded from the hand and foot muscles following transcranial magnetic stimulation (TCS) during complete relaxation and active contraction of the target muscles. Threshold intensities corresponded to the stimulator's output eliciting liminal MEPs in about 50% of stimuli during relaxation. It was found that threshold values of magnetic TCS were significantly higher in the elderly (44 +/- 6.4% vs 39 +/- 3.5% for the hand; 66 +/- 10.1 % vs 56 +/- 6.7% for the foot; P < 0.001) than in the young subjects. Moreover, this index progressively increased with age (P < 0.001), whilst the propagation time along the central motor tracts did not parallel such an age-related trend.

引用

页码：14 / 19

页数：6

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