DOWN-REGULATION OF MATERNAL ANTIPHOSPHOLIPID ANTIBODIES DURING EARLY-PREGNANCY AND PREGNANCY OUTCOME

OBJECTIVE: We investigated the hypothesis that maternal autoimmune responses to phosphilipid antigens measured before and during pregnancy are not related to successful pregnancy outcome. STUDY DESIGN: One hundred twenty-three women with recurrent spontaneous abortions were serially tested for antiphospholipid antibodies during their pregnancies. RESULTS: In 72 women with recurrent spontaneous abortions and without antiphospholipid antibodies before the pregnancy, the incidence of antiphospholipid antibody production at the time of pregnancy termination was significantly higher in those who miscarried the index pregnancy than those who were delivered of a live-born infant. In 51 antiphospholipid antibody-positive women with recurrent spontaneous abortions there were dramatic increases in titers of anticardiolipin antibody and antiphosphatidylserine antibody in those who miscarried the index pregnancy (p < 0.005). In women who were delivered of a live-born infant, the titers remained stable or decreased during pregnancy. CONCLUSIONS: Down-regulation of antiphospholipid antibody production during early pregnancy is associated with favorable pregnancy outcome.