INSULIN-LIKE GROWTH-FACTOR MESSENGER-RNA EXPRESSION IN TISSUES OF LEAN AND OBESE MALE SHFF/MCC-FA(CP) RATS

被引：2

作者：

DESEVILLA, L

MCCUNE, SA

WHITE, ME

机构：

[1] OHIO STATE UNIV,OHIO AGR RES & DEV CTR,DEPT ANIM SCI,COLUMBUS,OH 43210

[2] OHIO STATE UNIV,DEPT FOOD SCI & TECHNOL,COLUMBUS,OH 43210

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 1994年 / 109卷 / 2-3期

关键词：

INSULIN-LIKE GROWTH FACTORS; IGF-1; IGF-2; MESSENGER-RNA; OBESITY; CORPULENT RAT;

D O I：

10.1016/0305-0491(94)90020-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

No differences were detected in serum IGF-I levels between lean and obese male SHFF/Mcc-fa(cp) rats expressing non-insulin-dependent diabetes mellitus (NIDDM). In contrast, serum insulin levels, and blood glucose levels were significantly elevated in obese as compared to lean littermates (P < 0.05), indicating that the obese animals were diabetic. Northern blot analyses of total tissue RNA using labeled cDNAs for IGF-I and IGF-II revealed a decrease in liver and adipose IGF-I mRNA expression in the obese littermates while IGF-II mRNA expression was decreased only in adipose tissue of obese animals as compared to lean littermates.

引用

页码：371 / 382

页数：12

共 26 条

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[2]

BOLZE MS, 1991, J NUTR BIOCHEM, V2, P623, DOI 10.1016/0955-2863(91)90028-4

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