MICROTUBULE-ASSOCIATED PROTEINS IN ADULT HUMAN SENSORY ORGANS

被引：4

作者：

ANNIKO, M

ARNOLD, W

机构：

[1] Departments of Otorhinolaryngology and Head and Neck Surgery, Uppsala University Hospital (Akademiska sjukhuset), Uppsala

[2] Hals-Nasen-Ohren-Klinik und Poliklinik, Technischen Universität München, Klinikum rechts der Isar, München

来源：

ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES | 1995年 / 57卷 / 02期

关键词：

LABYRINTH; HAIR CELLS; HUMAN; MICROTUBULE-ASSOCIATED PROTEINS; IMMUNOMORPHOLOGY; CYTOSKELETON; MICROTUBULES;

D O I：

10.1159/000276715

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

The distribution of microtubule-associated proteins MAP-1 and MAP-2 was analysed with immunomorphological techniques in the serially sectioned adult human membranous labyrinth. In the organ of Corti, monoclonal antibodies to MAP-1 did not stain. Positivity for MAP-2 occurred in the entire outer hair cell cytoplasm, in the inner hair cells (?), in the nerve fibres and in the cytoplasm of epithelial cells of the spiral prominence. In addition, staining for MAP-2 was identified in many (but not all) cells or Reissner's membrane. Immunofluorescence for MAP-1 occurred in the supporting cells of the cristae and maculae interpreted to be localized in the apical region adjacent to the sensory cells. Thus, the distribution of MAP-1 and MAP-2 in the adult human membranous labyrinth was the same as described for several animal species with regard to the cochlea. In contrast to such a pattern, both MAP-1 and MAP-2 were identified in the human vestibular organs, thus identifying a subpopulation of centrally located nerve calyces and possibly also the apical portion of vestibular hair cells.

引用

页码：78 / 81

页数：4

共 19 条

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