REPEATED COCAINE ADMINISTRATION REDUCES 5-HT1A-MEDIATED PROLACTIN SECRETION IN RATS

被引：20

作者：

BAUMANN, MH

ROTHMAN, RB

机构：

[1] Clinical Psychopharmacology Section, Division of Intramural Research, NIDA Addiction Research Center, Baltimore, MD 21224, 4940 Eastern Avenue, Building C

来源：

NEUROSCIENCE LETTERS | 1995年 / 193卷 / 01期

关键词：

COCAINE; SEROTONIN (5-HT); 5-HT1A RECEPTORS; PROLACTIN; SEROTONIN SYNDROME;

D O I：

10.1016/0304-3940(95)11652-D

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The prolactin and behavioral responses elicited by the 5-HT1A agonist 8-OH-DPAT (8-hydroxy-2-{di-n-propylamino}tetralin) were examined in male rats previously exposed to chronic cocaine (15 mg/kg, i.p., b.i.d., 7 days) or saline. After 42 h of withdrawal, cocaine-treated rats exhibited a reduced prolactin response to 8-OH-DPAT challenge (50 mu g/kg, i.v.). A 5-fold higher dose of 8-OH-DPAT stimulated maximal prolactin secretion that was similar in cocaine- and saline-treated rats. Prior cocaine treatment had no effect on the 5-HT syndrome induced by 8-OH-DPAT. Our data agree with the findings of others and suggest that 5-HT1A receptors mediating neuroendocrine secretion become subsensitive after repeated cocaine administration.

引用

页码：9 / 12

页数：4

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