TESTOSTERONE METABOLISM IN ISOLATED PERFUSED HUMAN FOETAL LIVER

被引：7

作者：

DEMISCH, K

AMMEDICK, U

STAIB, W

机构：

[1] Institut für Physiologische Chemie der Universität Düsseldorf-1, Düsseldorf, BRD-4000

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 1969年 / 8卷 / 02期

关键词：

D O I：

10.1111/j.1432-1033.1969.tb00525.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The isolated liver of a female pre‐viable foetus was perfused with [4‐14C]testosterone. 6β‐Hydroxy‐testosterone, 6β‐hydroxy‐androstenedione, 2β‐hydroxy‐testosterone and androstenedione could be isolated from the perfusion medium. These compounds have been characterized by their gas‐chromatographic behaviour on a SE‐30 and XE‐60 column, as free steroids, acetates and trimethylsilyl ethers. Furthermore 2β‐hydroxy‐testosterone as diacetate was crystallized to constant specific activity. Copyright © 1969, Wiley Blackwell. All rights reserved

引用

页码：284 / &

共 12 条

[1]

BENAGIANO G, 1968, ACTA ENDOCRINOL-COP, V57, P187, DOI 10.1530/acta.0.0570187

[2]

DEMISCH K, IN PRESS

[3] 2-HYDROXYLATION OF ESTRADIOL BY HUMAN PLACENTAL MICROSOMES [J].