GENTAMICIN PHARMACOKINETICS IN KWASHIORKOR

被引：22

作者：

BUCHANAN, N

DAVIS, MD

EYBERG, C

机构：

[1] UNIV WITWATERSRAND,JOHANNESBURG 2001,SOUTH AFRICA

[2] BARAGWANATH HOSP,DEPT PAEDIAT,METAB & NUTR RES UNIT,JOHANNESBURG 2013,SOUTH AFRICA

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1979年 / 8卷 / 05期

关键词：

D O I：

10.1111/j.1365-2125.1979.tb01024.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1 Single dose intravenous gentamicin kinetics (2.4 mg/kg) were studied in six children with kwashiorkor. It was observed, that therapeutic drug concentrations were achieved which should be neither oto‐ nor nephrotoxic. 2 Due to the diminished glomerular filtration and renal plasma flow seen in the acute phase of kwashiorkor, gentamicin half‐ life was prolonged (229.0 +/‐ 94.8 min) at this time returning to normal (178.5 +/‐ 99.5 min) with nutritional rehabilitation. 1979 The British Pharmacological Society

引用

页码：451 / 453

页数：3

共 14 条

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[9] DRUG-METABOLISM AND PHARMACOKINETICS IN MALNUTRITION
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